Abstract

ROMERO, Adriana; ORLANDI, Walter  and  GONZALEZ, Juan Carlos. Colorectal cancer: characteristics of the expression of K-ras oncogene. Gen [online]. 2016, vol.70, n.2, pp.048-053. ISSN 2477-975X.

Introduction: Colon cancer ranks fourth leading cause of cancer death in adults. Objective: To describe characteristics of the expression of K-ras oncogene in patients with colorectal cancer (CRC) who attended the outpatient Gastroenterology of the University Hospital of Caracas (HUC) in the period from january-july 2014. Methodology: Transversal, descriptive and prospective court. The study population consisted of patients diagnosed with CRC by colonoscopy and histology with molecular evaluation of K-ras. Results: Of the 35 patients 57,14% were male and 42,86% female with a mean age of 57±17 years old; 100% of the sample corresponded to ADC histology predominating moderately differentiated rate (40.00%). 28 patients (80%) had no mutation of K-ras while 7 (20,00%) did, of which 6 (85,71%) reported mutation at codon 12 and 1 in the 13 (14,28%); in 4 of 7 patients (57,14%) mutation was in the left colon. Conclusions: K-ras mutation predominates in males with an average age of 57 years old and is present in 20% of the population; mutation in codon 12 is most frequently associated with the left colon and the most commom type of CRC by histology is the well differentiated ADC.

Keywords : K-ras; colorectal cancer; oncogene; mutation.