Resumo

ROMERO, Gisela. Microbiota intestinal their influence on chronic liver disease. Role in hepatocellular carcinoma. Gen [online]. 2016, vol.70, n.2, pp.064-069. ISSN 2477-975X.

The increase of the translocation of intestinal bacteria is characteristic of patients with chronic liver disease and promotes inflammation and fibrosis of the liver.^1-3 Has been involved in the intestinal microbiota in the pathogenesis and progression of liver diseases such as liver disease Fat Non-alcoholic, non-alcoholic steatohepatitis, Primary sclerosing cholangitis, liver disease by intestinal failure and hepatocellular carcinoma. Numerous investigations into the matter, come by noting that the intestinal microbiota and the toll-like receptors (TLRs) promote the Hepatocellular carcinoma (HCC).^1-4 The Hepatocarcinogenesis involves TLR4 and the intestinal microbiota, but these, are not required for the initiation of the HCC but for their promotion, through the increase of the proliferation, expression of the epiregulina hepatomitogena and the prevention of apoptosis.^4-6

Palavras-chave : liver cirrhosis; microbiota; hepatocellular carcinoma; Toll-like receptors.