Introduction:

Serological markers are useful in the early diagnosis and monitoring of celiac disease (CD). Considering that most of them are of the IgA isotype, and selective IgA deficiency represents one of the most frequently reported primary immunodeficiencies, the objective of this research was to detect this immunodeficiency and establish reference values for IgA on the Venezuelan population.

Materials and Methods:

The study was conducted on 308 individuals, of all ages and cities from the country, with and without a previous diagnosis of CD. We used immunoturbidimetric method and compared both groups to see if there were differences.

Results:

The values showed a p>0,05 concluding that patients with or without CD showed no significant differences in values of total serum IgA, discarding any case selective IgA deficiency. The reference values resulted in a range from 43.63 to 583.75 mg/dL (mean 313.69mg/dL, D =obext-obcontinua/R<1/3R).

Conclusions:

In the studied population, no cases of selective IgA deficiency and reference values were established according to the characteristics of our venezuelan population. We suggest increasing the number of determinations, in order to establish possible differences by groups of age.