Resumen

REYNA-VILLASMIL, Eduardo et al. Peroxidación lipídica en embarazos con preeclampsia y diabetes. Rev Obstet Ginecol Venez [online]. 2002, vol.62, n.2, pp.93-96. ISSN 0048-7732.

Objective: To evaluate oxidative stress and antioxidant defense system in preeclamptic diabetic, preeclamptic no diabetic and gestational diabetic women in relation to blood glucose levels. Method: The study was carried out in 83 women. The first group consisted of 25 patients with preeclampsia; 12 with diabetes, and 13 without diabetes. The second group of 33 normotensive pregnant women of which 8 had gestational diabetes and the remaining 25 were healthy pregnant women. The control group consisted of 25 healthy nonpregnant women aged 18-40 years. Heparinized venous blood were collected in the morning after 12 hours of fasting. The lipid peroxidation produce malonaldehyde that was estimated by thiobarbituric acid test. Vitamin E levels were estimated by spectrofluorometry after extraction of the vitamin from plasma into hexane. Setting: "Dr. Nerio Belloso" Maternity "Dr. JA Urquinaona" Central Hospital. Results: Malonaldehyde was enhaced in both preeclamptic and preeclamptic diabetic women as compared to healthy controls (P< 0.001). Malonaldehyde levels were higher in preeclamptic women as compared to preeclamptic diabetics < 0.05). A significant fall in vitamin E was observed in both preeclamptic as well as preeclamptic diabetic patients (P< 0.001). Conclusions: These findings suggest that lipid peroxidation plays a role in the pathogenesis of preeclampsia.

Palabras clave : Lipid peroxidation; Gestational diabetes; Preeclampsia; Preeclamptic diabetics; Vitamin E.