Resumen

REYNA-VILLASMIL, Eduardo; TORRES-MONTILLA, Marielys; REYNA-VILLASMIL, Nadia  y  MEJIAS-MONTILLA, Jorly. La combinación estradiol-acetato de noretisterona sobre los niveles del tromboxano B2 en mujeres posmenopáusicas. Rev Obstet Ginecol Venez [online]. 2002, vol.62, n.4, pp.257-260. ISSN 0048-7732.

Objective: To investigate plasma thromboxane B2 levels in postmenopausal women before and after administration of estradiol-norestisterone acetate and to compare with the levels of premenopausal women. Method: 30 postmenopausal patients were selected with a body mass index less than 30 kg/m2, and 22 premenopausal women. Postmenopausal women were treated with 2 mg of estradiol and 1 mg of noretisterone acetate daily during 6 months, and were in their follicular phase of artificial hormone replacement therapy cycle the time of sampling. Tromboxane B2 (final product of tromboxane A2 was analyzed using a radioimmunoassay test. Setting: TxB2 plasma levels were as follows 198 ± 83.2 pg/mL in premenopausal women, 1 215 ± 153.8 pg/mL in postmenopausal women before treatment and 711 ± 99.1 pg/mL in postmenopausal women after treatment. 6 months treatment with estradiol-noretisterone acetate led to a statically significant reduction of thomboxane B2 in postmenopausal women (p< 0.01). Difference was also significant when postmenopausal women were compared with premenopausal women both before and alter treatment. Conclusions: There is an increased production of thomboxane B2 in postmenopausal women, which probably reflects the increase of oxidative stress seen in menopause. After 6 months of daily treatment with estradiol-noretisterone acetate combination decreased plasma thomboxane B2.

Palabras clave : Thromboxane; Menopause; Hormone replacement therapy.