Resumen

REYNA-VILLASMIL, Eduardo; TORRES-MONTILLA, Marielys; REYNA VILLASMIL, Nadia  y  MEJIA-MONTILLA, Jorly. Homocisteína plasmática en pacientes con síndrome de ovarios poliquísticos. Rev Obstet Ginecol Venez [online]. 2003, vol.63, n.2, pp.87-94. ISSN 0048-7732.

Objective: To determine homocysteine levels in patients with polycystic ovary syndrome and insulin resistance non-treated. Method: 19 patients who suffered of polycystic ovary syndrome were included in this study. Control group consisted in 10 women, with regular menstruation and normal ultrasonographic ovaries. Hormonal assay, lipid profile, ecographic evaluation and detennination of homecysteine were made. Setting: Hospital Central "Dr. Urquinaona", Maracaibo.Results: Evidence was found of a significant high level of homocysteine in patients with polycystic ovary syndrome when compared with controls (12.3 ± 3.1 vs. 6.8 ± 1.5 ng/dL; p< 0.05). Mean level of serum insulin was signiftcant higher (23.3 ± 10.4 vs. 12.4 ± 1.2 mU/mL; p< 0.05) and levets of sexual hormone biding globulin were significant lower (1.76 ± 0.6 vs. 3.5 ± 0.9 mg/mL; p< 0.001), in cases en polycystic ovary syndrome when compared with controls confirming a higher incidence of this metabolic disorder in polycystic ovary syndrome. Conclusions: These observations give evidence of significant difference of plasmatic concentrations of homocysteine in patients with polycystic ovary syndrome and normal subjects, although mean levels of homocysteine were within the normal range for both groups.

Palabras clave : Homocysteine; Polycystic ovary syndrome; Insulin resistance.