Resumen

REYNA-VILLASMIL, Eduardo; TORRES-MONTILLA, Marielys; REYNA-VILLASMIL, . Nadia  y  MEJIA-MONTILLA, . Jorly. Terapia hormonal de reemplazo y niveles plasmáticos de homocisteína y proteína C reactiva . Rev Obstet Ginecol Venez [online]. 2003, vol.63, n.2, pp.95-100. ISSN 0048-7732.

Objective: To investigate effect of estrogens compared with hormone replacement therapy with estrogen progestin over plasma homocysteine and C-reactive protein levels at 6 months in healthy menopausal women. Methods: Fifty-six postmenopausal women were included. Patients were treated: Group A: 0,625 mg/day of natural conjugated estrogens, and Group B: 2 mg of estradiol and 1 mg of norestestirone acetate. Concentrations of total serum cholesterol, low-density lipoprotein, high-density lipoprotein, tryglicerides, plasma homocysteine and C reactive protein were measured. Setting: Hospital Central "Dr. Urquinaona", Maracaibo.Results: Of 56 women, 26 received natural conjugated estrogens and the rest 30 received estradiol norestestirone acetate. Estrogens alone increased significantly concentrations of C-reactive protein (p< 0.05), but combined treatment does not produce significant changes of it. However, both treatments reduced significantly plasma homocysteine levels (p< 0.05). After 6 months of treatment, mean concentrations of homocysteine decreased in 21.8 % in group A and 29.2 % in group B. Conclusions: The reduction of plasma homocysteine levels with both treatments may contribute to cardiovascular benefit of the use of hormonal replacement treatment and increased of C-reactive protein induced by estrogens could be partially prevented by addition of progesterone to treatment.

Palabras clave : Homocysteine; C-reactive protein.; Hormone replacement therapy.