Resumen

REYNA-VILLASMIL, Eduardo; TORRES-MONTILLA, Marielys; REYNA-VILLASMIL, Nadia  y  MEJIAS-MONTILLA, Jorly. Fosfolipasa A₂-II sérica durante el ciclo menstrual, embarazo y puerperio. Rev Obstet Ginecol Venez [online]. 2003, vol.63, n.3, pp.129-133. ISSN 0048-7732.

Objective: To evaluate phospholipaseA₂-II circulating levels during normal menstrual cycle and determine alterations in maternal circulating phospholipaseA₂-II concentrations during menstrual cycle, pregnancy and puerperium. Method: Serum phospholipaseA₂-II concentrations were compared among 28 non-pregnant women with normal menstrual cycle, 57 normal pregnant women and 11 women at seventh day of puerperium. Also were measured in 8 patients with threatened premature labor. phospholipaseA₂-II levels before and after delivery were made to determine differences in 8 neonates delivered vaginally and 8 neonates delivered by cesarean section. A 10-mL blood sample was obtained in the morning and an immunoradiometric assay, using two monoclonal antibodies, to determine serum phospholipaseA₂-II. Results: Serum phospholipaseA₂-II concentrations at luteal phase were significantly lower than those at menstrual o follicular phase (p< 0,05). There was no significant difference in serum phospholipasA₂-II levels between normal pregnant women and patients with threatened premature labor. Serum phospholipaseA₂-II concentrations at seventh day post-partum were significantly higher than those in normal pregnant women. Conclusions: These results suggest that a regulatory mechanism of phospholipaseA₂-II may exist during the normal menstrual cycle and at puerperium.

Palabras clave : Phospholipase A₂; Menstrual Cycle; Pregnancy; Puerperium.