Resumen

REYNA-VILLASMIL, Eduardo; GUERRA-VELASQUEZ, Mery; REYNA-VILLASMIL, Nadia  y  MEJIAS-MONTILLA, Jorly. Efecto de la combinación estradiol - acetato de noretisterona sobre los niveles de proteína c reactiva en menopáusicas ooforectomizadas. Rev Obstet Ginecol Venez [online]. 2005, vol.65, n.3, pp.129-132. ISSN 0048-7732.

Objective: To determine the effect of estradiol and norethisterone acetate on serum C reactive protein levels in healthy oophorectomised postmenopausal women at baseline and at 3, 6, 9 and 12 months. Method: Thirty six patients, who underwent hysterectomy and bilateral salpingo-oophorectomy with climacteric symptoms were included. Patients were treated with 2 mg of estradiol and 1 mg of norethisterone acetate daily. C reactive protein were measured at baseline and at 3, 6, 9 and 12 months. Setting: Hospital Central "Dr. Urquinaona". Maracaibo. Estado Zulia Results: An increased of C reactive protein was observed at 3 months, but it was consider not significant (p > 0,05). Later, non significant variations were observed at 6, 9 and 12 months related to initial value (p > 0,05). Conclusion: Oral administration of estradiol and nortisterone acetate do not produce increase of C reactive protein levels in oophorectomised postmenopausal patients, which could contribute to cardiovascular benefit of users of combined hormonal replacement therapy.

Palabras clave : Menopause. C-Reactive protein; Estradiol; Nortisterone acetate; Oophosectomised postmenopausal.