Resumen

REYNA-VILLASMIL, Eduardo et al. Concentraciones de estradiol y acetato de noretisterona y mediciones antropométricas en menopáusicas obesas y no obesas. Rev Obstet Ginecol Venez [online]. 2006, vol.66, n.3, pp.172-177. ISSN 0048-7732.

Objective: To determine the effects of estradiol and norethisterone acetate on hormonal concentrations and anthropometric measures in obese and non obese postmenopausal women. Setting: "Dr. Urquinaona" Central Hospital. Maracaibo, Estado Zulia. Methods: Sixty postmenopausal women were selected, thirty of them were treated with 2 mg of estradiol and 1 mg norethisterone acetate daily. The other group of patients did not have history or use any kind or combination of hormonal replacement therapy. Weight, height, estrone, estradiol, growth hormone, insulin-like growth factor 1, cortisol and androstenodione were measured. Results: Estrone and estradiol were higher in estradiol and norethisterone acetate users compared with non users (P < 0.05). Obese users of the combination had higher concentrations of estradiol than non obese users (P < 0.05). Non obese users of the combination had higher concentrations of growth hormone than other groups of postmenopausal women. Concentrations of insulin-like growth factor 1 were significantly lower in obese women users of combination (P < 0.05). Non obese users of estradiolnorethisterone acetate had concentrations of cortisol significantly higher. Conclusions: The use of estradiol-norethisterone acetate produces a significant increase in growth hormone and cortisol concentrations with significant lower concentrations of insulin-like growth factor 1 in non obese postmenopausal women. Combinations should be used carefully in obese women due to high serum concentrations observed.

Palabras clave : Menopause; Hormonal concentrations; Anthropometric measures; Obesity.