Resumen

REYNA-VILLASMIL, Eduardo et al. Efectos del estradiol y acetato de noretisterona sobre los lípidos y la lipoproteína (a) sérica en posmenopáusicas ooforectomizadas.. Rev Obstet Ginecol Venez [online]. 2007, vol.67, n.1, pp.41-46. ISSN 0048-7732.

Objective: To determine the effects of estradiol and norethisterone acetate combination on lipid profile and lipoprotein (a) in healthy oophorectomized postmenopausal women. Method: Thirty six patients who underwent hysterectomy and salpingo-oophorectomy with climacteric symptoms were included. Patients were treated with 2 mg of estradiol and 1 mg of norethisterone acetate daily for 12 months. Serum concentrations of triglycerides, HDL cholesterol, LDL cholesterol, cholesterol and lipoprotein (a) were measured at baseline and at 3, 6, 9 and 12 months of treatment. Setting: Hospital Central “Dr. Urquinaona”, Maracaibo. Results: There were not statically significant changes in mean values of cholesterol, triglycerides and LDL cholesterol after 3, 6, 9 and 12 months of treatment when compared with baseline values (P = ns). An increased in HDL cholesterol values were seen since 3 first months of treatment. During the first 3 months of treatment lipoprotein (a) levels did not vary significantly (P = ns). From 6 months of treatment, and at 9 and 12 months, these serum levels raised significantly when compared with baseline values (P < 0,05). Conclusions: Oral administration of estradiol and norethisterone acetate produces significant changes in HDL and lipoprotein (a) values, without affecting serum concentrations of cholesterol, triglycerides and LDL cholesterol in oophorectomized postmenopausal women.

Palabras clave : Lipids; Lipoprotein; Estradiol; Norethisterone acetate; Post menopause; Oophorectomy.