Abstract

REYNA-VILLASMIL, Eduardo et al. Homocisteína y óxido nítrico en preeclámpticas en pre y posparto. Rev Obstet Ginecol Venez [online]. 2007, vol.67, n.3, pp.167-173. ISSN 0048-7732.

Objectives: To compare the concentrations of homocysteine and nitric oxide in preeclamptic and normotensive pregnant women in pre and post-partum and to establish a relation between both compounds in the different studied periods. Methods: Groups consisted in 35 preeclamptic patients (group A) and 35 normotensive pregnant women (group B, controls). Blood samples to determine homocysteine and nitric oxide concentrations were recollected before labor and seven days and six weeks after delivery. Setting: Maternidad "Dr. Nerio Belloso", Hospital Central "Dr. Urquinaona", Maracaibo.  Results: There were significant statically differences in gestational age at the moment of study, systolic and diastolic pressure, newborn weight and presence of proteinuria (P < 0.05). Homocysteine concentrations during pre and post-partum were significantly higher in preeclamptic compared with group B (P < 0.05). In relation to nitric oxide concentrations, there were statically significant differences between group A and B in all studied periods (P < 0.05). There was also a significant negative strong correlation between homocysteine and nitric oxide previous to delivery, at seven days and six weeks of post-partum (P < 0.001). Conclusions: Preeclamptic presented higher concentrations of homocysteine and lower of nitric oxide compared to normotensive pregnant women with a negative strong correlation between them in pre and post-partum

Keywords : Nitric oxide; Homocysteine; Preeclampsia.