Resumen

ATIAS RICOVERI, Farith. Receptores de estrógenos en posmenopáusicas. Rev Obstet Ginecol Venez [online]. 2008, vol.68, n.1, pp.41-46. ISSN 0048-7732.

Objective: To evaluate the relationship between the vaginal clinical and physiological recuperation, and the increase of estrogen receptors in postmenopausal women, after administration of estrogens alone or combined with progestogens. Method: Thirty postmenopausal women divided into two groups were studied, 8 hysterectomized patients received 0.625 mg of conjugated equine estrogens continuous orally, and 22 patients intact uterus that additionally received medroxyprogesterone acetate at doses of 0,5 mg orally during 12 days every month. Vaginal biopsy before and 4 months after treatment as well as estrogen receptor determinations were performed. Setting: Hospital Universitario de Caracas and private practice of the author. Results: Age ranged between 49 and 71 years. Mean level of estrogen receptors before and after treatment were 7,30 ± 6,47 and 45,40 ± 26,87 respectively and this difference was statistically significant. There was a significative difference in the response to the two therapies, been more pronounced with estrogens without opposition that with combine treatment with basal measure of 6,40 ± 3,83 against 61,34 ± 33,35 and 7,68 ± 7,52 against 38,19 ± 21,00 respectively. Response of vaginal dryness and dyspareunia was significative, but not the vaginal contraction. Conclusion: The study shows an increase of vaginal mucosa estrogen receptors in postmenopausal women that received hormonal therapy during 4 months. The increase was higher in patients that received only estrogens.

Palabras clave : Post menopause; Unopposed therapy; Combined therapy; Estrogen receptors; Vaginal.