Abstract

REYNA-VILLASMIL, Eduardo et al. Efecto del citrato de sildenafil sobre el flujo sanguíneo de las arterias uterina, umbilical y cerebral media fetal en preeclámpticas. Rev Obstet Ginecol Venez [online]. 2008, vol.68, n.3, pp.187-194. ISSN 0048-7732.

Objective: To establish the effect of sildenafil citrate over blood flow of uterine, umbilical and fetal middle cerebral artery in preeclamptic patients. Methods: A total of 30 preeclamptic patients (group A) and 30 normotensive pregnant patients (Group B) were blood flow of uterine, umbilical and fetal middle cerebral artery were analyzed. Pulsatility index, resistance index and systolic / diastolic ratio of each artery were analyzed. Treatment was 50 mg of sildenafil citrate twice a day (100 mg/day) per two days in preeclamptic group (Group A). Setting: Maternidad "Dr. Nerio Belloso". Hospital Central "Dr. Urquinaona". Maracaibo, Estado Zulia. Results: There were not significant statically differences related to maternal and gestational age (p = NS). Initial Doppler measurements showed statically significant differences when compared to normotensive control patients (P < 0.01). After the use of sildenafil in the group A, there was found a significant reduction in pulsatility index, resistance index and systolic / diastolic ratio in uterine artery when compared to mean initial values (P < 0.01). Conclusion: Sildenafil citrate produces a significant improvement over blood flow of uterine arteries without affecting blood flow of umbilical and fetal middle cerebral artery.

Keywords : Sildenafil; Preeclampsia; Doppler ultrasound.