Resumen

TORRES-CEPEDA, Duly et al. Tocólisis con clorhidrato de isoxuprina o nifedipina en la amenaza de parto pretérmino. Rev Obstet Ginecol Venez [online]. 2010, vol.70, n.1, pp.11-17. ISSN 0048-7732.

Objective: To compare the efficacy of isoxuprine clorhidrate or nifedipine in tocolysis of threatened preterm labor. Methods: 82 patients with a gestational age between 24 and 34 weeks and threatened preterm labor diagnosis were selected. Patients were randomly divided in 2 groups to receive isoxuprine clorhidrate (group A) or nifedipine (group B). Time of cease of contractions, maternal blood pressure, glucose concentrations and maternal adverse effects were determined. Setting: Maternidad "Dr. Nerio Belloso", Hospital Central "Dr. Urquinaona", Maracaibo. Estado Zulia. Results: An effective tocolysis was obtained within 24 hours in 61.0 % and 70.7 % for patients in group A and B, respectively (P = ns). After 7 days of treatment, 36.6 % of patients in group A and 31,7 % of patients in group B were still without contractions (P = ns). A delay in labor till 34 weeks or more was made in 26.8.% and 29.3 % of patients in group A and B, respectively. In the group of patients treated with isoxuprine clorhidrate a significant raise of glucose concentrations was observed (P < 0.001). Maternal adverse effects were significant more frequent in isoxuprine clorhidrate group after 2 and 24 hours of treatment (P < 0,05). Conclusion: Nifedipine has a similar effectivity than isoxuprine clorhidrate for tocolysis in threatened preterm labor and produces less adverse effects.

Palabras clave : Isoxuprine; Nifedipine; Threatened preterm Labor.