Resumo

GIUSTINIANO, Belvian; RODRIGUEZ, Sheila; ABACHE, Enrique  e  HURTADO, Félix. Uso de la metformina en el tratamiento de pacientes infértiles con síndrome de ovarios poliquísticos. Rev Obstet Ginecol Venez [online]. 2010, vol.70, n.4, pp.249-253. ISSN 0048-7732.

Objective: To determine the effect of treatment with metformin in infertile patients with polycystic ovary syndrome. Methods: Clinical, prospective and descriptive study. Infertile anovulatory patients with polycystic ovary syndrome and insulin resistant were included, and all of them, were treated with metformin for 3 months. Patients who did not ovulate in this time, received clomiphene citrate for 6 months. Setting: Fertility Service of Maternidad "Concepcion Palacios". Results: 62 infertile patients were included in this study. The pregnancy rate was 25.8 % (19 patients). The 57.9 % of women became pregnant with metformin administration for 3 months, with P= 0.492, it was not statistical significance. The pregnancy rate with clomiphene citrate was 23.5 % (8 patients), P= 0.684. The abortion rate was 26.3 % (5). Conclusion: The metformin induce ovulation in anovulatory polycystic ovary syndrome women, whereas the pregnancy rate resulted similar in both treatment groups: metformin alone and metformin and clomiphene citrate.

Palavras-chave : Metformin; Clomiphene citrate; Polycystic ovary syndrome; Insulin resistant.