Abstract

LOPEZ DE SANCHEZ, Mercedes et al. Infección por virus papiloma humano en pacientes con células escamosas atípicas de un programa de pesquisa de cáncer cervical. Rev Obstet Ginecol Venez [online]. 2012, vol.72, n.1, pp.19-27. ISSN 0048-7732.

Objective: To evaluate the frequency of human papillomavirus infection in patients with atypical squamous cells of a cervical cancer detection program.Method: Between March 2006 to December 2009, specimens for cervical smears and human papillomavirus molecular detection by PCR-RFLP were taken from the patients attended at the cervical cancer clinic prevention. Setting: Facultad de Farmacia y Bioanálisis. Laboratorio Asistencial “Lic. Celina Sánchez Rincón y Facultad de Ciencias, Laboratorio de Biología y Medicina Experimental LABIOMEX. Universidad de Los Andes. Mérida, Estado Mérida, Venezuela. Results: A total of 2 805 patients were evaluated, those with atypical squamous cells of undetermined significance and atypical squamous cells that cannot exclude a high intraepithelial lesion were chosen. Abnormalities in epithelial cells were found in 4,31 %. Atypical squamous cells were found in 58 (2,06 %) of the cases, 1,85 % were atypical squamous cells of undetermined significance and 0,21 % were atypical squamous cells that cannot exclude a high intraepithelial lesion. The overall prevalence of human papillomavirus infection was 32/58 (53,4 %). High risk human papillomavirus was found in 10/58 (17,2 %)of the patients, most of them between 21 and 30 years old. Human papillomavirus could not be determinedin 16/58 (27,5 %) of the cases. Conclusions: It was observed a high frequency of human papillomavirus in patients with atypical squamous cells in their cervical smears.

Keywords : Cytology; Atipical squamous cells; Atypical squamous cells of undetermined significance; Atypical squamous cells that cannot exclude a high intraepithelial lesion; PCR-RFLP; Cervical smear; Human papillomavirus.

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