Resumen

RUSSO DI NOVELLA, Anna Caterina; PIZZI LA VEGLIA, Rita; SALAZAR, Mauricio  y  PENA NUNEZ, Neyra Iraima. Protección gonadal de pacientes con malignidades hematológicas durante la quimioterapia: Uso del acetato de leuprolide. Rev Obstet Ginecol Venez [online]. 2012, vol.72, n.1, pp.42-51. ISSN 0048-7732.

Objective: To demonstrate the role gonadotropin releasing hormone analogues in ovarian reserve in hematology patients in the hematology service at the Hospital Universitario de Caracas in 2010, treated with chemotherapy regimens. Method: Study of ovarian reserve variable by periodic quantification of: menstrual rhythm, concentrations of FSH, ovarian volume, antral follicle number and incidence of pregnancy. Leuprolide acetate was administered (11.25 mg) intramuscularly every 3 months, were measured quarterly and FSH concentrations were performed pelvic or transvaginal ecosonograms every 6 months. Results: After aGnRH administration, we observed the occurrence of amenorrhea in patients. FSH concentrations were stable, and followed the same distribution (Levene test p 0.2466) ovarian volume and antral follicle numbers were stable, we reject the hypothesis of normality of group differences at 5% significance. There were no pregnancies. Conclusion: Ovarian reserve is preserved during continuous treatment with analogs.

Palabras clave : Ovarian reserve; aGnRH; Chemotherapy.

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