Abstract

AGUERO, Anna; CASTILLO, Kharem  and  GONZALEZ BLANCO, Mireya. Neoplasia intraepitelial cervical de alto grado en mujeresmenores de 25 años y mayores de 45 años. Rev Obstet Ginecol Venez [online]. 2012, vol.72, n.2, pp.89-102. ISSN 0048-7732.

Objectives: To assess the characteristics of patients under the age of 25 and over 45 years with diagnosis of cervical intraepithelial neoplasia II-III. Methods: Retrospective, descriptive and comparative study of 334 patients with cervical intraepithelial neoplasia II-III diagnostic consulting to Maternidad Concepcion Palacios, in 2005-2009, distributed in:20.7 % under the age of 25 (Group A) 64.8 % between 25-45 (Group B) and 14.4 % over the age of 45 (Group C). Results: El 23.1 % had cervical intraepithelial neoplasia II and 76.9 % cervical intraepithelial neoplasia III. The onset of sexual activity was 15.5 ± 2, 16.9 ± 2.6 and 17.8 ± 3 years, respectively (P=0.001), the first pregnancy occurred 15, 19 and 20 years for each group (P=0.001). The number of pregnancies was 1, 2 and 4 respectively (P=0.01). There was 43.9 % of smokers in Group C (P=0,001) and 29.6 % of patients who are immunosuppressed in Group A (P< 0,05). The disturbances of epithelial cells on cytologyof 3 groups were predominated. There were no differences in the colposcopy, therapeutic or in rates of healing, persistence or recurrence. In Group A, 85.7 % of persistent injuries were low grade (P< 0.05). Conclusions: The more important risk factors in Group A were: early onset of sexual relations, early first pregnancy, number of pregnancies and immunosuppression. In Group C were: greater parity, smoking, and higher body mass index. The clinic, treatment and evolution were similar with 20 % of persistence and less than 10 % of relapses.

Keywords : CIN II-III; Epidemiology; Risk factors.

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