Resumen

RIVAS, Elvia; VERLEZZA, Silvanna  y  FLORES, Mercedes. Distribución genotipo-específico del virus papiloma humano entre hombres y mujeres de Caracas, Venezuela. Rev Obstet Ginecol Venez [online]. 2012, vol.72, n.3, pp.171-176. ISSN 0048-7732.

Objective: Determine the distribution of HPV in men and women with Molecular Biology techniques in order to provide epidemiological information to evaluate the usefulness of the HPV vaccine in the population. Methods: Samples of endocervical swabs, urethral, preputial, biopsies and cervical scrapes for DNA extraction: Body Fluid Kit AxyPrep Viral DNA / RNA Miniprep (Axygen) for the amplification: INNO-LIPA HPV Kit Extra Genotyping. Data were collected in the electronic system Infolab. 1 545 patients in total were separated by sex, age group and HPV DNA amplification. Results: 77.6 % of male patients and 67.9 % of females were positive for HPV DNA amplification. We found a positive peak between 30 and 34 years of age (24.3 %) as well as for males (20.0 %). Among females 50.6 % of genotypes identified corresponded to HR-HPV, 22.4 % to HPV-LR, 27.0 % for other genotypes. In males, 41.3 % were HR-HPV, HPV-LR 34.6 % and 24.2 % other genotypes. AR genotypes detected more frequently were HPV- 52/51/16 and LR were HPV-6/11. Conclusions: Cervical cancer is a public health problem. Cytology screening has had no impact on the prevalence, we suggest the use of more sensitive tests. It is necessary to evaluate the use of the vaccine in conjunction with other strategies, analyzing the strengths and weaknesses identified, in order to establish optimal prevention programs.

Palabras clave : HPV; Cervical cancer; Vaccine.

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