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Revista de Obstetricia y Ginecología de Venezuela
versión impresa ISSN 0048-7732
Resumen
CARRERA R, Joana Liz; FIGUEIRA F, José Valentin y GONZALEZ BLANCO, Mireya. Imiquimod en el tratamiento de la infección vulvar por virus de papiloma humano. Rev Obstet Ginecol Venez [online]. 2012, vol.72, n.4, pp.261-268. ISSN 0048-7732.
Objective: To determine the efficacy of imiquimod as medical treatment of infection by HPV vulvar. Method: Descriptive, prospective, longitudinal study in which 30 patients with genital warts received imiquimod cream 5 % every 48 hours, for 12 weeks. The area of application was assessed weekly for a month and a vulvoscopia was made at 3, 6 and 12 months after treatment. Results: The average age of the patients was 27.7 ± 6.5 years. The most common injuries were exophytics, 30% were located in fork and 30 % were multifocal. At three and six months of treatment, obtained a total improvement of 96.7 per cent and 3.3 per cent of persistence (P<0.001) and after one year of follow up 83.3 % were cured, there were 13.3 % of recurrence and in 3.3 % injury persisted (P<0.001). 66.7 % of the patients had mild side effects during treatment, pain (26.7 %) and the burning predominated (23.3 %). The difference between the proportion of symptomatic and asymptomatic was statistically significant. No patient discontinued therapy. For the month of completed treatment, 73.3 % said not symptoms (P=0.0003). Epidemiological variables and characteristics of the injury did not affect the result. Conclusion: The imiquimod is effective in the treatment of vulvar infection by HPV, with mild adverse effects tolerated by patients, with low recurrence and persistence and high cure rates.
Palabras clave : HPV; Imiquimod; Vulva; Tolerance.