Resumen

REBOLLEDO-P, Vilma E  y  COLOMBO-S, Carla J. Expresión de KI67, P53, BCL2 en el carcinoma de mama en nuestro medio. Rev Obstet Ginecol Venez [online]. 2014, vol.74, n.1, pp.47-53. ISSN 0048-7732.

Objective: To determine the expression of Ki67, p53 and Bcl2 in patients diagnosed with breast cancer in our midst. Methods: A descriptive, retrospective design nonexperimental transeccional expression by immunohistochemistry of molecular markers Ki67, p53 and Bcl2 in cases with a diagnosis of breast cancer in a group of 110 consecutive women attending a breast query the Jarales Teaching Clinic (CDLJ) during the period from 2005 to 2011. The sample was composed of intentional and file cases selected records of the query that met the following inclusion criteria. Results: The mean age was 51.81 years, over 60 % were postmenopausal. The tumor was located in most of the left breast, over 60 % of the tumors had a size between 2-5 cm and over 80 % regional metastases. In more than half of the tumors was observed immunoexpression hormone receptors. 60 % of the tumors corresponded to the luminal subtype A. Ki67 was observed in the highest percentage of cases in tumors from patients aged 25 to 46 years and the p53 and Bcl2 in those between 36 to 46 and 58 to 68 respectively. The Ki67, p53 and Bcl2 marked in more cases classified clinical stage II-III, as tumors between 2-5 cm and more than 7 metastatic nodes. Conclusion: It is necessary to generate further evidence on the characteristics of our female population affected by neoplasia to understand their behavior accordingly rationalize them and what matches your therapy.

Palabras clave : Breast cancer; Immunohistochemical expression; Female population; Venezuela.

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