Resumen

JIMENEZ, Libia; GOMEZ, Miriam  y  GARCIA DE BARRIOLA, Victoria. Tumores metastásicos al ovario. Estudio clínicomorfológico. Rev Obstet Ginecol Venez [online]. 2015, vol.75, n.1, pp.041-048. ISSN 0048-7732.

Objective: To determine the clinical and morphological characteristics of metastatic tumors to the ovary. Methods: A descriptive retrospective study of 25 patients who underwent surgery at the University Hospital in Caracas, and diagnosed at the gynecological pathology section of the Anatompathological Institute “Dr. José A. O´Daly”. Tumors were classified according to their anatomic origin in gynecologic and nongynecologic. Clinical and morphologic features were evaluated. Determination of mucopolysaccharides and glycogen and an immunohistochemical panel including cytokeratin 7, cytokeratin 20, alfa inhibin and CA125 antigen, was performed. In the remaining cases, immunohistochemistry was done according to tumor origin. Results: The group of gynecological origin represented 36 % of the cases, median age 49,66 years. The most frequent motives for consultation were abdominal pain and weight loss. Primary tumor was confirmed in all the cases and they all measured less than 10 cm in diameter. The non-gynecologic group represented 64 % of the cases with a median age of 42,68 years. Consultation was due to increased abdominal girth, abdominal pain and gastrointestinal disturbances. 10/19 cases measured over 10 cm in diameter. The immunohistochemical study of digestive cases were CK7-/CK20+ in four mucinous adenocarcinomas originated in the colon and four Krukenberg tumors. The other three Krukenberg tumors were CK7+/ CK20+ as was a tumor originated in the gall bladder. A pancreatic originated tumor was CK7+/CK20-. Conclusion: Immunohistochemical studies are useful to orient hystogenesis of metastatic ovarian tumors. Clinical-morphologic correlation is determinant for the definitive diagnosis.

Palabras clave : Metastasis; Ovary; Clinical; Morphologic.

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