Resumen

PIZZI, Rita et al. Niveles de hormona antimülleriana en pacientes con síndrome de ovario poliquístico. Rev Obstet Ginecol Venez [online]. 2015, vol.75, n.4, pp.250-259. ISSN 0048-7732.

Objective: To determine the values of antimülleriana hormone in patients with polycystic ovary syndrome who were treated at the Gynecology office of the University Hospital of Caracas between March to September 2013. Methods: A prospective, descriptive and longitudinal study with simple sequential sampling of 30 patients between the ages of 18-39 who met the Rotterdam criteria was performed. Antimülleriana hormone determinations were performed using a 3.5 value as a control for polycystic ovary syndrome. Antimülleriana hormone levels were determined in the different age groups and hormone values were then correlated according to the presence of ovulatory or anovulatory cycles and its relationship with BMI and androgen levels. Results: 30 patients were recruited for the study: 20 % (6/30) between 18 and 24 years old, 56.5 7 % (17/30) between 25-30 years old, 16. 7 % (5/30) between 31-36 years old and 6. 7 % (2/30) between 37-40 years old. The BMI ranged between 19 and 48 kg/m² with a median of 26.10 kg/m². The antimülleriana hormone values ranged between 1.90 and 22.20, x = 10.22. 3.33 % (1/30) had values less than 3 and 96.6 7 % (29/30) exceeded this value. Antimülleriana hormone values were established for the different age groups. The Pearson correlation coefficient between BMI and antimülleriana hormone yielded a value of r = 0.03 suggesting a very low direct relationship between the two variables. When considering the anovulatory cycles condition dependent of antimülleriana hormone, the eta coefficient value reached 0.95 with a very high relationship, where 24 anovulatory patients with antimülleriana hormone values ranging between 4.80 and 22.20, x = 10, 86. The Pearson correlation coefficient r = -0.03 indicates a very low inverse relationship between the antimülleriana hormone and the 17OHPG. Also the Pearson correlation coefficient r = 0.04 indicates a very low direct relationship between antimülleriana hormone and testosterone. Conclusions: The antimülleriana hormone is elevated in patients with polycystic ovary syndrome (values greater than 3). No significant relationship was found between antimülleriana hormone and BMI levels and a very low direct relationship with the presence of biochemical hyperandrogenism. However, a dependency among the anovulatory cycles dependent of the higher values of antimülleriana hormone was found.

Palabras clave : Polycystic ovary syndrome; Antimülleriana hormone; Oligomenorrhea.

        · resumen en Español     · texto en Español     · Español ( pdf )