Resumen

JARAMILLO-MONSALVE, María Camila; MARTINEZ SANCHEZ, Lina María  y  JARAMILLO-JARAMILLO, Laura Isabel. Polimorfismos genéticos asociados a complicaciones crónicas de la menopausia. Rev Obstet Ginecol Venez [online]. 2016, vol.76, n.1, pp.60-66. ISSN 0048-7732.

Menopause is a hormonal transition associated to ovarian senescence, usually presenting between 45 and 59 years after a progressive decrease in the reproductive capacity until termination, the menopause is marked by the absence of menstrual periods after 12 consecutive months. It is characterized by a broad clinical profile, including hot flashes (flushing), dyspareunia, sleep disorders, among others. Despite much research there is no clear evidence about a treatment which overcome the effectiveness of hormone replacement therapy (HRT). A field that has become the target of current research is the genetic polymorphisms and their relation to changes in the presentation of the different conditions associated with menopause such as cardiovascular risk, osteoporosis and breast cancer.

Palabras clave : Menopause; Climateric; Estrogens; Hot flashes; Hormone replacement therapy; Breast neoplasms; Polymorphism; Genetic.

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