Resumen

RUIZ, Fabián Andrés; MUNOZ MARIN, Ana Melissa  y  GUTIERREZ MEJIA., María José. Obstetric management of a pregnant patient with hereditary angioedema, first reported case in Colombia. Rev Obstet Ginecol Venez [online]. 2025, vol.85, n.2, pp.294-298.  Epub 06-Nov-2025. ISSN 0048-7732.  https://doi.org/10.51288/00850220.

Hereditary angioedema (HA-1) is a rare genetic disorder caused by a deficiency of complement C1 inhibitor. It is characterized by intermittent edema of the skin, membranes, mucosa, and organs due to elevated levels of bradykinin. We present the case of a 28-year-old primigravida with a prior diagnosis of HA-1 who experienced recurrent cutaneous edematous attacks during pregnancy, managed with C1 inhibitor concentrate (Berinert®). At 37 weeks and 6 days, the patient developed gestational hypertension and went into labor, leading to an uncomplicated elective cesarean section, with complete monitoring in the obstetric intensive care unit and no edematous crises during the puerperium. This case underscores the importance of having obstetric intensive care units and the availability of prophylactic and acute treatment options to ensure maternal and fetal safety. This is the first reported case in Colombia.

Palabras clave : Hereditary angioedema; Complement C1 inhibitor; Intensive care units; Rare disease; Pregnancy.

        · resumen en Español     · texto en Español     · Español ( pdf )