Objective:

To evaluate the use of the autologous endocervical patch based on platelet-rich plasma, due to its modulating and stimulating properties of the cell proliferation process, useful in tissue regeneration, in a group of pregnant women with premature rupture of the membrane.

Methods:

Observational, descriptive, prospective, and cross-sectional research, which included 20 patients with singleton pregnancy between 23 and 34 weeks, with premature rupture of membranes, preserved fetal well-being, without clinical or paraclinical signs of chorioamnionitis or uterine contractions. An autologous patch of platelet-rich plasma was administered transcervically, under controlled conditions; Maternal-fetal clinical and paraclinical parameters were monitored and the clinical evolution of the binomial was observed.

Results:

Pregnancy was prolonged by more than 7 days by 40%, the amniotic fluid index after patch was elevated (p < 0.05). Newborns with latency greater than 7 days (42.9%) were directly attached to their mother (p < 0.05); There was a weight gain about 600 grams more than their peers with less prolonged pregnancies.

Conclusion:

The results obtained significantly demonstrate the therapeutic effectiveness of the autologous platelet-rich plasma patch improving pregnancy prolongation, amniotic fluid index and survival of newborns, being a viable alternative in premature rupture of membranes for cases with rigorous inclusion criteria, which could have a benefit in the reduction of maternal-fetal complications. in selected patients.