Resumen

RIVAS MELENDEZ, Andreina R et al. Histopatological Findings in Natural Infected Dogs with Leishmania Infantum, Bolivar Country, Aragua State. Rev. Fac. Cienc. Vet. [online]. 2017, vol.58, n.2, pp.86-95. ISSN 0258-6576.

Leishmaniasis is a metaxenic disease, worldwide distributed. This disease is produced by several species of protozoa of the genus Leishmania and is transmitted by vectors (sandflies) of the genus Lutzomyia. Leishmaniasis has been classified in cutaneous, muco-cutaneous, and visceral. Leishmania infantum is the species responsible for the visceral pattern and the canine (Canis familiaris) is the main reservoir. The tropism of L. infantum induces the symptomatology and the tissue damage in canine visceral leishmaniasis, which is characterized by the symptomatic triad of high fever, hepato-splenomegaly and leucopenia, followed by pancitopenia. This disease causes local damage at the site of inoculation due to the interaction between the parasite and the regional macrophages and to nonspecific dermatological manifestations, clinically located within the asymptomatic, oligosymptomatic, and polysymptomatic patterns of the disease. In this investigation, a total of 14 canines from Topo I, Topo II, and Las Cumbres de Zamora, from the Bolívar municipality of the State of Aragua, Venezuela, showed seropositivity to L. infantum (using the rK39 antigen). To perform the histopathological study, 7 of them were taken 3 skin samples of 10 anatomical points. The histological sections for the microscopic study were obtained using the hematoxilin-esosin technique. As a result of the infection, antibodies were generated. From the clinical standpoint, the animals showed asymptomatic or oligosymptomatic patterns, with nonspecific lesions in diverse anatomical regions. No cellular changes were evident; however, in the epidermis, areas with hyperkeratosis, acanthosis, and neutrophilic infiltrate were observed in sweat and sebaceous glands; in the dermis, a lymphohistioplasmocytic inflammatory infiltrate and interstitial or interfibrillar edema was detected; in the hypodermis, neovascularization and periductal lymphoplasmatic inflammation was noted. No amastigotes were evident in phagocytic cells.

Palabras clave : Canine Leishmaniasis visceral; skin; histopathology.

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