Abstract

BOSCAN, Ana; NUNEZ-GONZALEZ, María N; NUNEZ-GONZALEZ, José  and  NUNEZ-MOLERO, Marco. Fibrinógeno sérico en angina inestable como predictor de progresión a infarto agudo del miocardio. Gac Méd Caracas [online]. 2002, vol.110, n.3, pp.338-342. ISSN 0367-4762.

In onder to demonstrate that the serum measurements of fibrinogen help to predict the ocurrence of myocardial infarction in patients with unstable angina, sixty patients with diagnosis of unstable angina that went to Hospital Central Dr. Urquinaona in Maracaibo were studied. Myocardial infarction was discarded according to the approaches of the OMS. Two groups were formed according to the clinical evolution: group A, patients with unstable angina and Group B, patients who developed myocardial infarction. The serum measurements of fibrinogen and CPK-MB were determined at 6, 24, 48 and 72 hours of evolution (samples 1, 2, 3 and 4 respectively). The statistical analysis was carried out by means of the Student "t", Chi square and the test of correlation of Pearson as it corresponded. The group B represented fibrinogen, cholesterol and platelet counts significantly higher (P< 0.0001). In this group, the elevation of the CPK-MB in the samples 2,3 and 4 were significant higher (P< 0.0001). Equally they presented high levels of fibrinogen in all the samples (P< 0.05). There was positive correlation between the fibrinogen and the CPK-MB (r= 0.663, P< 0.0001). It is clear that the elevation of the fibrinogen to the beginning of the chest pain is a factor of independent risk that indicates the evolution of the unstable angina toward myocardial infarction, you can consider as predictor of adverse coronary event. The fibrinogen rose first that the CPK-MB circumstance that determines its possible use as prognostic marker of myocardial infarction in patient with unstable angina. This possible function as prognostic tool should be confirmed with studies that include more number of patients.

Keywords : Fibrinogen; Unstable angina; Myocardial infarction.