Abstract

SCHOLZ, Jannete; SUAREZ, Claudia  and  MOTA, José David. Mixomas cardíacos: estudio morfológico e inmunohistoquímico de 50 biopsias. Gac Méd Caracas [online]. 2007, vol.115, n.2, pp.126-137. ISSN 0367-4762.

Myxomas are the most frequent primary tumors of the heart. Fifty cardiac biopsies of myxomas were analyzed by histopathology, in 24 of which, the immunohistochemical was done. Patients (M/F: 19/31) whose ages were between second and seventh decade of life, presented varied sintomatology, were operated with the diagnosis of tumor and/or intracardiac mass. The most frequent location of myxomas was in left (86.0 %) and right (8.0 %) auricles. Macrocospically, they presented gelatinous and mixoide aspect, one single case was petrified. They measured between 3 and 10 cm and 50.0 % were pediculate. To the light microscope, they were characterized by: isolated cells or forming vascular structures (94.0 %), seudopapilars (54.0 %) and pseudo glandulars (4.0 %); abundant mixoide matrix with inflammatory cells (96.0 %), hemorrhage (94.0 %), nodules of Gamna-Gandi (30.0 %) and calcifications (18.0 %). The immunohistochemical study revealed: positive marker in the tumorlike cells: vimentine (100.0 %), CD34 (83.0 %), actine smooth muscle (37.0 %) desmine (17.0 %). The marker for S-100 were negative and the cytoqueratine (A1/AE3) was positive in a single case with glandular differentiation. Conclusions: on the base of the immunohistochemical study, we considered that evidences exist that support the mesenquimal origin of the tumor with predominant differentiation towards the endotelial line.

Keywords : Key words; Cardiac myxomas; Cardiac tumors; Immunohistochemical.