Abstract

HERNANDEZ, Alipio; CESPEDES, Ghislaine  and  TREJO, Ernesto. Estudio clínico-patológico comparativo de los meningiomas con referencia a su grado histológico y riesgo de recidivas. Gac Méd Caracas. [online]. 2008, vol.116, n.2, pp.104-114. ISSN 0367-4762.

The histological grade of the Wordl Health Organization and the extension of the initial surgical resection have been considered determining prognostic factors in meningiomas. Nevertheless, a recurrence rate close to20 % in benign meningiomas completely resected arises the need of considering new prognostic factors. In order to estimate the importance of the histological grade andto determine the influence of clinical and morphologicalfactors upon the risk of recurrences in meningiomas, a comparative clinical-pathological study was carried out on 580 tumors (belonging to 532 patients). Progression of the histological grade was evident in a significant percentage of male patients in addition to a major invasive quality of the tumor to adjacent structures and a higher percentage of recurrent tumors, while the age of the patient, the localization and size of the tumor, the extension of the initial surgical resection and the interval free from recurrencies, did not vary with the histological grade. No significant differences were observed when comparing non recurrent meningiomas and recurrent meningiomas with respect to the gender and age of thepatients, histological grade, localization and size of thetumor, extension of the initial surgical resection andtumorous invasion of adjacent structures. While thehistological grade of the meningiomas is important topredict their biological behaviour, there are no reliable clinical or morphological parameters able to determinethe prognosis for a particular histological grade (especiallywithin the group of benign meningiomas).

Keywords : Meningioma; Histological grade; Recurrencies.