Abstract

HERNANDEZ, Alipio; CESPEDES, Ghislaine  and  TREJO, Ernesto. Expresión inmunohistoquímica de la proteína p53 en relación con el grado histológico y riesgo de recidivas en meningiomas intracraneanos. Gac Méd Caracas. [online]. 2008, vol.116, n.3, pp.198-211. ISSN 0367-4762.

Meningiomas are frequent primary neoplasms of the central nervous system, usually benign and susceptible to healing through surgery. The histological grade of the World Health Organization and the extension of the initial surgical resection, are determining prognostic factors in these tumors. Nevertheless, a recurrence rate close to 20 % in benign meningiomas completely resected arises the need of considering new prognostic factors. A total of 93 cases were selected for the immunohistochemical study of p53 protein in relation to the histological grade and the risk of recurrences in meningiomas. The immunohistochemical labeling index of p53 protein increased with the progression of the histological grade (means of 37,15 % for grade I, 44,49 % for grade II, and 57,81 % for grade III) and was significantly superior in recurrent meningiomas (46,19 % vs 32,29 % of non recurrent). The cut off of 40 % became statistically useful to separate the benign meningiomas (grade I) from the non benign (grade II and III) and the recurrent tumors from the non recurrent. In this way, a labelling index of p53 protein equal or superior to 40 % can indicate the possibility of a higher grade in histologically ambiguous cases or a higher risk to develop recurrencies in meningiomas of a particular histological grade (specially in benign tumors).

Keywords : Meningioma; Inmunohistochemical; p53 protein.