Resumen

REYNA-VILLASMIL, Eduardo et al. Ácido úrico como indicador pronóstico de severidad de la excreción urinaria de proteínas en 24 horas. Gac Méd Caracas. [online]. 2008, vol.116, n.3, pp.219-223. ISSN 0367-4762.

Objective: To establish the role of uric acid concentration as prognostic indicator of 24-hours urinary protein excretion severity. Methods: Patients with diagnosis of preeclampsia which uric acid and urinary protein excretion could be determined were selected. Blood samples were recollected in all patients before delivery and immediately after diagnosis. Setting: Hospital Central “Dr. Urquinaona”. Maracaibo, Estado Zulia. Results: Mean value of urinary protein excretion was 4,1 ± 2.0 grams in 24 hours and uric acid of 7.2 ± 1.6 m g/dL, showing a moderate, positive and significant correlation (r = 0.518; P < 0.001). Using a value of 7 m g/dL to divide patients in two groups, there were statically significant difference in 24-hour urinary protein excretion (P < 0.05). There was also statitiscally significant differences in gestational age at the moment of delivery, body mass index, systolic and diastolic blood pressure (P < 0.05). Using it as a cutoff value, sensibility to detect a 2 4 -hour urinary protein excretion of 3 gram was 83.3 %, specificity of 75 %, positive predictive value of 62.5.% and negative predictive value of 90.0 % with and accuracy of 79.2 %. Conclusion: Uric acid concentrations statitiscally correlates w ith 24-hour urinary protein excretion.

Palabras clave : Preeclampsia; Uric acid; Urinary protein excretion.