Resumo

REYES CHILPA, Ricardo  e  HUERTA REYES, Maira. Natural compounds from plants of the clusiaceae family: Type 1 human immunodeficiency virus inhibitors. INCI [online]. 2009, vol.34, n.6, pp.385-392. ISSN 0378-1844.

AIDS being a worldwide public health problem, it is necessary to coordinate efforts to fight the disease. Under this viewpoint, we review research aiming at the discovery and development of new drugs against the human immunodeficiency virus (HIV) from secondary metabolites of vegetal origin, isolated from species of the clusiaceae family. Particularly, the review centers on tetracyclic cumarines that inhibit the HIV-1 reverse transcriptase, such as the (+)-calanolide A. A summary of HIV biology and the studies carried out in Mexico concerning the search of anti-HIV compounds from the local flora is also presented.

Palavras-chave : Calophyllum; Clusiaceae; Cumarinas; SIDA; VIH.