Abstract

REYNA-VILLASMIL, Eduardo et al. Comparative Study of Intravaginal Misoprostol Effect at 50 and 100 µg in Cervical Ripening and Labor Induction. . Invest. clín [online]. 2005, vol.46, n.2, pp.179-186. ISSN 0535-5133.

The objective of this work was to compare the efficacy of 50 and 100 µg of misoprostol administered intravaginally for cervical ripening and labor induction. Ninety-five patients were randomly assigned to receive 50 µg (n = 48) or 100 µg (n = 47) of misoprostol. The primary measures in this study were cesarean section rate, time from induction to delivery, need for oxytocin use, rate of uterine hyperstimulation and tachysystoles, proportion of fetal distress and neonatal Apgar score. The interval from first dose of prostaglandin to delivery was significantly shorter in the 100 µg-group (p < 0.05). The use of oxytocin augmentation was significantly higher in the 50 µg-group (64.6% vs. 31.9%). There were 9 cases (18.8%) of tachysystole in the 50-µg group and 12 cases (25.5%) in the 100 µg-group (p NS). The cesarean section rate was double in the 100 µg-group and the difference was statically significant (p < 0.05). There was no report of uterine rupture. It can be concluded that 50 µg of misoprostol applied in the posterior vaginal fornix every 4 hours is an effective dosage for labor induction and has less adverse effects and complications than the100 µg dose.

Keywords : Misoprostol; cervical ripening; labor induction.