Resumen

LUCENA, Sara; AROCHA PINANGO, Carmen Luisa  y  GUERRERO, Belsy. Fibronectin: Structure and functions associated to hemostasis. Review. Invest. clín [online]. 2007, vol.48, n.2, pp.249-262. ISSN 0535-5133.

Fibronectin is an adhesive glycoprotein present in a soluble form in plasma and in an insoluble form in the extracellular matrix of many tissues. The human plasma level of this protein is about 300 ± 100 µg/mL. It is synthesized and secreted by a wide variety of cells, consequently is one of the components of greater distribution in the body that participates in the biochemical reactions of diverse physiological and pathological processes. Due to the presence of multifunctional domains in its structure, fibronectin interacts with diverse components of the coagulation and fibrinolysis. It may bind to collagen, fibrinogen, fibrin, heparin, factor XIII and platelets, among others, regulating processes of importance in hemostasis such as: platelet adhesion and aggregation, tissue remodelling during wound healing, and activation of fibrinolysis by the plasminogen activators.

Palabras clave : Fibronectin; adhesive proteins; wounds healing; hemostasis; platelets; integrins.

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