Abstract

LEAL, Jorymar Y; ROMERO, Tania; ORTEGA, Pablo  and  AMAYA, Daisy. Serum values of interleukin-10, gamma-interferon and vitamin A in female adolescents. Invest. clín [online]. 2007, vol.48, n.3, pp.317-326. ISSN 0535-5133.

Many studies have demonstrated that vitamin A deficiency (VAD) affects the immunomodulated response mediated by cytokines. However, these studies are controversial. The purpose of the present study was to analyze Interleukin-10, gamma-Interferon and vitamin A serum concentrations in adolescents. Seventy three female, not pregnant adolescents (15.95 ± 1.10 years old), of a low socioeconomic condition were studied. Serum retinol was determined by HPLC using the Bieri method. International reference standards were considered to define VAD (serum retinol < 20µg/dL), risk of VAD (20-30µg/dL) and vitamin A sufficiency (>30µg/dL). Serum concentrations of Interleukine-10 (IL-10) and gamma-Interferon (gamma-IFN) were detected by an ELISA method (pg/mL). The data were analyzed using the SAS/STAT statistical program; the results were presented as mean ± Standard deviation and the differences between mean values were analyzed by the ANOVA test. The prevalence of VAD in adolescents was 6.85% (serum retinol <20µg/dL) and 41.10% adolescents had VAD risk (20-30µg/dL). Adolescents with VAD showed a significant increase of gamma-IFN serum concentration (p = 0.01). Correlation between serum retinol and gamma-IFN was r = -0.29 (p = 0.01). Adolescents represent a VAD risk group. Low serum levels of retinol were correlated with high levels of gamma-IFN, this cytokine has been associated with chronics inflammatory processes and it can contribute to increase the morbidity and mortality in this population.

Keywords : Cytokines; vitamin A; adolescents.

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