Resumen

URICH, Daniela et al. Effect of hypocapnia/alkalosis on the fluid filtration rate in isolated and perfused rabbit lungs. Invest. clín [online]. 2008, vol.49, n.2, pp.181-193. ISSN 0535-5133.

Hypocapnia/alkalosis is a consequence of several lung and metabolic pathologies. The aim of this study was to determine whether the increase of fluid filtration rate (FFR) that occurs during Hypocapnia/alkalosis circumstances is determined by hypocapnia, alkalosis or both. 7 groups were formed (N=36) using isolated rabbit lungs. Group 1: Control (PCO₂ 6%, pH: 7.35-7.45); Group 2 (n=6): Hypocapnia/Alkalosis (CO₂ 1%, pH: 7.9); Group 3 (n=6): Hypocapnia/Normo-pH (CO₂ 1% pH 7.35-7.45), Group 4 (n=6) Normocapnia/Alcalosis (CO₂ 6%, pH: 7.9). Fenoterol, papaverine and hydrocortisone were added to Groups 5, 6 and 7 (n=4) respectively, all under Normocapnia/Alkalosis. FFR and Pulmonary Arterial Pressure (Pap) were considerably higher in group 2 than in control (FFR:1.92g/min ± 0.6 vs 0.0g/min ± 0.006). A strong influence exerted by pH was observed when Group 3 and group 4 were compared (FFR: 0.02g/min ± 0.009 vs 2.3g/min ± 0.9) and (Pap: 13.5 cmH₂O ± 1.4 vs 90 cmH₂O ± 15). A reduced effect was observed in groups 5 and 6 (papaverine and hydrocorisone) and a totally abolished effect was observed in group 7 (fenoterol) (FFR: 0.001 ± 0.0003 mL/min and Pap: 14±0.8 cmH₂O). Pulmonary edema induced by Hypocapnia/alkalosis is a consequence of alkalosis and not of hypocapnia. This effect could be due to inflammatory damage in the lung parenchyma and alkalosis-mediated vasoconstriction.

Palabras clave : Hypocapnia; alkalosis; lung edema; fenoterol; hydrocortisone; papaverine; rabbit.

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