Abstract

CAMPOS, Gilberto  and  GRUPO FRICVE et al. Relationship of fibrinogen with cardiovascular risk factors in healthy men from Maracaibo, Venezuela. Invest. clín [online]. 2008, vol.49, n.3, pp.341-351. ISSN 0535-5133.

The purpose of this paper was to determine the relationship between fibrinogen concentration and cardiovascular ischaemic risk factors in a group of apparently healthy men from Maracaibo, Venezuela. Two hundred and forty six individuals, ages 31 to 65 years were evaluated by means of clinical and laboratory examination. In each person plasma fibrinogen concentration was measured by coagulometry, serum glucose and lipids by enzymatic methods and insulin by radioimmunoanalysis. 31.7% of subjects had fibrinogen values in the highest tertil of the whole group (³ 311 mg/dL), they also showed significantly higher values of total cholesterol (p< 0.03) and LDL-C (p < 0.01). In addition, the individuals in this tertil showed a significant and positive correlation between the values of triglycerides with insulin (p< 0.02) and with HOMA-IR (p < 0.01). On the other hand, correlation analysis also showed a positive significant association between the fibrinogen levels and total cholesterol (p < 0.02), dependent of individuals with family history of ischaemic cardiovascular disease (total cholesterol: p< 0.02 and LDL-C: p < 0.003). In consideration of the high concentrations of fibrinogen found in 31.7% of apparently healthy men and their significant positive correlation with total cholesterol and LDL-C, on the group of men with a family history of ischaemic cardiovascular disease, it would be advisable to include the determination of fibrinogen in the cardiovascular evaluation of these particular subjects.

Keywords : Fibrinogen; cardiovascular disease; lipids; insulin; HOMA-IR.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )