Resumo

GARCIA-TAMAYO, Jorge; MOLINA, Julia  e  BLASCO-OLAETXEA, Eduardo. Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix: Review. Invest. clín [online]. 2009, vol.50, n.2, pp.241-250. ISSN 0535-5133.

Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteíns like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, b-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papilloma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).

Palavras-chave : Immunohistochemistry; cervical intraepithelial neoplasia; cervical cancer; HPV; genetic alterations.

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