Resumo

RADA, Elsa; ARANZAZU, Nacarid  e  CONVIT, Jacinto. Immune response of Hansen´s disease: Review. Invest. clín [online]. 2009, vol.50, n.4, pp.513-527. ISSN 0535-5133.

Hansen’s disease presents a wide spectrum of clinical and histopathological manifestations that reflect the nature of the immunological response of the host towards diverse Mycobacterium leprae components. The immunological system, composed by both innate and adaptive immunology, offers protection towards infections of various etiologies, among them bacterial. Bacteria, of course, have developed multiple strategies for evading host defenses, based on either very complex or simple mechanisms, but with a single purpose: to “resist” host attacks and to be able to survive. We have tried to summarize some recent studies in Hansen’s disease, with more emphasis in the inmunology area. We think that in the future, all illnesses should also be very strongly related to other important aspects such as the social, environmental and economic, and whose development is not solved in a laboratory.

Palavras-chave : Hansen’s disease; immune response; innate immunity; adaptative immunity; genetic influences; reaction leprosy.

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