Resumo

PENA-SANOJA, María Johanna  e  DE SANCTIS, Juan Bautista. Autophagy and immune response. Invest. clín [online]. 2013, vol.54, n.3, pp.325-337. ISSN 0535-5133.

Autophagy is a complex process in which cell homeostasis of proteins, organelles, exocitic and endocitic vacuoles are controlled. There is a direct link between autophagy and cell death with antigen processing, generation of inflammatory response and immune response. In different diseases, deficiencies in autophagy have been reported. It has been proposed that in early stages of cancer, autophagy is capable of inducing cell death; however, in agresive tumors and metastasis, the process is responsible for pharmacologic resistance and tumor survival. More research has to be done in order to allow us to understand the process and generate therapeutic options in different pathologies important for the human being.

Palavras-chave : autophagy; cell death; immune response; major histocompatibility complex; cancer.

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