Abstract

RAMIREZ ALVARADO, María Matilde  and  SANCHEZ ROITZ, César. Relationship between serum levels of C-reactive protein and α1-antitrypsin and insulin resistance in obese women. Invest. clín [online]. 2014, vol.55, n.3, pp.249-259. ISSN 0535-5133.

Adipose tissue produces cytokines involved in insulin resistance (IR) such as IL-6, IL-8, TNF-α and proinflammatory molecules such as C reactive protein (CRP). α1-antitrypsin is an inflammation-sensitive plasma protein. The objective of this study is to determine the correlation between serum CRP high-sensitivity (CRPhs) and α1-antitrypsin levels with IR indices in obese Venezuelan women. The study population consisted of 15 normal weight women (BMI 21.8 ± 1.9 kg/m²) and 15 obese women (BMI 35.3 ± 5.3 kg/m²). Obese and lean women underwent a 2 h-75g oral glucose tolerance test and the following indices were calculated: homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β cell function (HOMA-β), Matsuda Index and Insulinogenic Index. The relationship between serum CRPhs and α1-antitrypsin levels and these indices were determined. Obese women had higher CRPhs levels (p = 0.001) compared with normal weight women. In obese women, serum CRPhs levels were positively correlated with HOMA-IR (r=0.73, p=0.0021), HOMA-β (r=0.53, p=0.031) and negatively correlated with the Matsuda Index (r= -0.60, p=0.017). No correlation between serum levels of α1-antitrypsin and IR indices in the obese group and the lean group was observed. There was a relation between serum CRPhs levels and insulin resistance, suggesting a role of subclinical inflammation in IR.

Keywords : C reactive protein; a1-antitrypsin; insulin resistance; obesity.

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