Resumo

RAMIREZ-GARCIA, Sergio Alberto  e  GRUPO MULTIDISCIPLINARIO PARA EL ESTUDIO INTEGRAL DE LAS ENFERMEDADES METABOLICAS E INFECCIOSAS EN POBLACION MEXICANA et al. Association of the ELMO1 gene (snp rs1345365) with development of type 2 diabetes mellitus in the Mexican mestizo population. Invest. clín [online]. 2015, vol.56, n.4, pp.341-355. ISSN 0535-5133.

The g.37190613 locus on 7p14.2-14.1 in the ELMO1 gene has a G>A polymorphism (SNP rs1345365) that has been associated with diabetic nephropathy in different populations. The genetic-association studies in type 2 diabetes mellitus (DM2) on the Mexican population are limited. The aim of this study was to estimate whether the polymorphism G>A of ELMO1 gene is associated with the development of DM2. We included 148 DM2 individuals, 156 individuals with cardiovascular risk factors without diabetes and 269 healthy proband without DM2. The polymorphism was identified by PCR amplification specific allele (PASA), PAGE and silver staining. The association was established by genetic epidemiological models; the dominant model showed a positive association (p=0.0006) as a protective factor, and the para-dominant model to heterozygous, as risk factor. In conclusion, this study revealed the association of the SNP rs1345365 of the ELMO1 gene in a Mexican population.

Palavras-chave : ELMO1 gen; Type 2 diabetes mellitus; association study; extracellular matrix; diabetic nephropathy.

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