Abstract

ARVELO, Francisco; SOJO, Felipe  and  COTTE, Carlos. Contamination, endocrine disruptors and cancer. Invest. clín [online]. 2016, vol.57, n.1, pp.77-92. ISSN 0535-5133.

Since the mid-twentieth century, many species, very different from each other and located in all areas and corners of the planet, began presenting various alterations, many of which suggested to be related to endocrine disorders. Research has shown that such alterations were caused by exposure to various chemical contaminants that could affect the health and cause serious illnesses. Among them stands a diverse and large group of compounds, with very different chemical structures, capable of altering the hormonal balance, act at very low doses and with different mechanisms of action, that are called “endocrine disrupting chemicals”. When released into the environment or as part of objects, food or medicines, constitute a major risk to animals and humans, which produces not only endocrine dysfunctions but also different cancers, which include the most common types. Despite the importance and significance of the impact of these compounds, they are not sufficiently known or understood, so the aim of this review is to show their origin and impact in the field of human health, highlighting their role as inducers of cancer, which has led to multiple clinical and biological investigations.

Keywords : cancer; chemical exposure; endocrine disrupter; xenobiotic; xenoestrogens.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )