Abstract

SHENG, Liang; WU, Liang; XIA, Xianwu  and  LI, Junmiao. Analysis of the value of dynamic computed tomography (CT) examination in the diagnosis of early lung cancer. Invest. clín [online]. 2023, vol.64, n.2, pp.142-150.  Epub Sep 08, 2023. ISSN 0535-5133.  https://doi.org/10.54817/ic.v64n2a01.

Early diagnosis and treatment are vital to improving lung cancer patients’ quality of life and survival rate. This study aimed to investigate the value of dynamic enhanced scanning examination by computed tomography (CT) in early lung cancer diagnosis. One hundred and twenty patients with isolated lung nodules were selected to analyze this diagnostic method, using pathological diagnostic results of cancer as the gold standard. Of the 120 patients with isolated pulmonary nodules, the diagnosis was confirmed by pathological examination in 96 patients with early lung cancer (adenocarcinoma of the lung) and 24 patients with benign lung lesions. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CT dynamic enhancement scans for the diagnosis of early-stage lung cancer were 93.75%, 83.33%, 91.67%, 95.74%, and 76.92%, respectively. Early-stage lung cancer had significantly less blood volume and a noticeably shorter mean time to passage than benign lung lesions (p<0.01). Blood flow and surface permeability were higher in early-stage lung cancer than in benign lung lesions (p<0.05). The areas under the receiver operating characteristic (ROC) curves for blood volume, blood flow, surface permeability, and mean time to passage for the diagnosis of early-stage lung cancer were 0.737, 0.724, 0.779, and 0.946, respectively. In conclusion, CT dynamic enhancement scan has good application value in diagnosing early lung cancer and is worth promoting in clinical practice.

Keywords : CT dynamic enhancement scan; early stage; diagnostic value; blood flow.

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