Abstract

XU, Yansong  and  SHEN, Lin. Benefits of a modified local precision liver resection using intraoperative laparoscopic ultrasound in the treatment and prognosis of patients with liver cancer. Invest. clín [online]. 2024, vol.65, n.2, pp.155-168.  Epub June 03, 2024. ISSN 2477-9393.  https://doi.org/10.54817/ic.v65n2a03.

The incidence and mortality rate of liver cancer has increased significantly. Recently, intraoperative laparoscopic ultrasound (LUS) has been used in hepatectomy, in addition to open liver resection, as the most common treatment method. The current research aims to address this issue. Seventy-six patients with liver cancer who were admitted to the Hospital of Beihua University from February 2018 to September 2021 were randomly divided into two groups of 38 patients, one group undergoing conventional laparoscopic surgery (control group) and the other group undergoing a precise laparoscopic liver resection after placing an intraoperative LUS instrument (study group). Blood loss and hepatic vein damage during surgery were less in the study group (p<0.05). Seven days after surgery, liver function indices (albumin, total bilirubin, and alanine and aspartate aminotransferases) and indices related to immune function interleukin 6, tumor necrosis factor α, CD3+ and CD4+ T lymphocytes and NK cells level in the study group improved compared to the control group. The postoperative complications were less in the study group, and the nine-month follow-up showed that the recurrence rate was lower and the survival rate was higher in this group. This study shows that precise laparoscopic hepatectomy modified with the use of intraoperative laparoscopic ultrasound results in better intraoperative and postoperative outcomes for the prognosis and survival rate of patients with liver cancer, which makes this surgical technique worth generalizing in clinical practice.

Keywords : precision hepatectomy; liver function; hepatic venous injury; immune factors; immune response; cytokines; Karnofsky performance scale.

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