Abstract

KONG, Chunfeng  and  ZHU, Changdong. The effect of regular exercise combined with quantitative nutritional support on immune function indicators such as CD3+, CD4+, CD8+, and nutritional status in dialysis patients. Invest. clín [online]. 2024, vol.65, n.3, pp.346-357.  Epub Sep 14, 2024. ISSN 0535-5133.  https://doi.org/10.54817/ic.v65n3a07.

To study the effect of regular exercise and quantitative nutritional support on dialysis patients’ immune function indicators and nutritional status, 100 uremic patients who underwent hemodialysis treatment in our hospital from February 2021 to February 2023 were selected as the study subjects. They were divided into a control group (n=50) that received regular exercise and routine nutritional support, and a research group (n=50) that received regular exercise and quantitative nutritional support. This study compared the baseline levels of nutritional indicators such as prealbumin (PA), transferrin (TF), serum albumin (SAB), and hemoglobin (HB); cellular immune indicators such as CD3+, CD4+, and CD8+; as well as humoral immune indicators such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) at enrollment and after three months of intervention. At the time of enrollment, there were no significant differences in nutritional indicators between the two groups of patients (p>0.05), nor in the levels of cellular immune indicators (p>0.05) or humoral immune indicators (p>0.05). After three months of intervention, nutritional indicators such as PA in all patients in the experiment grew (p<0.05), and those in the research group exceeded the control group (p<0.05). Similarly, the levels of CD3+ and other cellular immune indicators and the concentrations of IgA and other humoral immune indicators increased in both groups after three months of intervention (p<0.05). However, these increases were higher in the research group than in the control group (p<0.05). Regular exercise combined with quantitative nutritional support can effectively improve hemodialysis patients’ nutritional index levels, nutritional status, immune index levels, and immune function.

Keywords : hemodialysis; immune function; nutritional status.

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