Abstract

YANG, Huamei. Rehabilitation training effect guided by cardiopulmonary fitness assessment on NT-proBNP levels in patients with chronic heart failure. Invest. clín [online]. 2024, vol.65, n.4, pp.406-417.  Epub Dec 10, 2024. ISSN 2477-9393.  https://doi.org/10.54817/ic.v65n4a01.

This study explored the impact of rehabilitation training guided by cardiopulmonary fitness assessment on NT-proBNP levels in patients with chronic heart failure (CHF). It was conducted on 220 chronic heart failure (CHF) patients from March 2020 to February 2022. They were divided into a control and observation group. The control group received routine nursing, while the an observation group underwent rehabilitation guided by a cardiopulmonary fitness assessment. Changes in NT-proBNP levels, vascular endothelial function, and cardiopulmonary function were compared between the groups at admission, eight, and 12 weeks later. Upon admission, the two groups had no statistically significant difference in NT-proBNP levels (p>0.05). However, after eight and 12 weeks of intervention, both groups showed decreased NT-proBNP levels, with the observation group exhibiting significantly lower levels than the control group (p<0.05). Similarly, there was no significant difference between the groups initially (p>0.05) in endothelial function comparison. However, after eight and 12 weeks, ET-1 and Ang-II levels decreased in both groups, with the observation group showing significantly lower levels than the control group (p<0.05). In terms of cardiopulmonary function, there was no significant difference initially. However, after eight and 12 weeks, Peak VO2, VO2 AT, and maximum exercise power increased in both groups compared to before the intervention, with the observation group showing significantly higher values than the control group (p<0.05). Additionally, the VE/VCO2 slope decreased in both groups post-intervention, with the observation group having a lower slope than the control group (p<0.05). Cardiopulmonary fitness-guided rehabilitation objectively evaluates patients, formulates precise plans, reduces NT-proBNP levels and inflammation, improves vascular endotelial function, and is vital in secondary chronic heart failure prevention.

Keywords : cardiopulmonary fitness assessment; cardiopulmonary function; chronic heart failure; plasma N-terminal B-type pronatriuretic peptide; rehabilitation training.

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