Resumen

WANG, Xinjie et al. Effect of early enteral nutrition on postoperative outcomes in pancreatic cancer patients with diabetes. Invest. clín [online]. 2025, vol.66, n.1, pp.89-100.  Epub 16-Abr-2025. ISSN 0535-5133.  https://doi.org/10.54817/ic.v66n1a08.

This study aimed to evaluate the impact of early enteral nutrition support in pancreatic cancer patients with diabetes mellitus following total pancreatectomy. Ninety-six patients were randomly divided into control and research groups, each with 48 patients. Both groups received parenteral nutrition, while the research group received additional enteral nutrition within the first 48 hours post-surgery. Results showed that the research group experienced faster recovery of bowel sounds, earlier first defecation, and shorter gastric tube retention times compared to the control group (p<0.05). Postoperative gastrointestinal function, immune function, and nutritional status were significantly better in the research group, with higher levels of gastrin, motilin, immunoglobulins G, A, and M, CD4/CD8 ratio, albumin, prealbumin, and transferrin (p<0.05). Furthermore, the research group had better blood glucose control from 48 hours to seven days post-surgery (p<0.05). The above results demonstrated a promoting impact of early nutrition support on postoperative physical functioning recovery of pancreatic cancer patients with diabetes mellitus. In conclusion, early enteral nutrition support in pancreatic cancer patients with diabetes mellitus significantly improved nutritional status, postoperative gastrointestinal recovery, gastrointestinal and immune function, and blood glucose control, leading to a better overall prognosis.

Palabras clave : diabetes mellitus; early enteral nutrition; gastrointestinal function; pancreatic cancer.

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